Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity

You don't wanna stimulate the sympathetic nervous system so much for so often. It can probably shorten your life. There's a whole category of what are called growth hormone secretagogues, which are very popular. People hear erection, fat loss, energy, tan, like, oh, great. This isn't the kind of thing you do to, like, go on vacation. You gotta be real careful with these things.

Nearly one in seven Americans is taking a GLP-one drug. Twenty percent have tried them. What do you think the future looks like?

In theory, you could eradicate obesity. People can lose up to a third of their body weight. Melanotan, which makes people tan from the inside, raises energy and libido dramatically, fat loss dramatically. BPC one five seven, body protection compound. It's not legal, but it's not necessarily enforced. They list them as for research purposes only, not for human use. I mean, who's doing research on these peptides at home? Anytime you're stimulating cell growth, it could start going awry and may then get a tumor or something like that. If that's within your margins of brisk, then that's up to you.

I wanna talk about what's happened over the last five years.

Slowly through the eighties, through the nineties, and then the early two thousands, everyone wanted to know what they could take to improve their immune system and their health. There's a very interesting drug that I think is gonna become far more popular soon, which is

When the pandemic hit, people wanted to know what they could take to protect themselves. The first thing that broke out was vitamin D, innocuous enough that doctors didn't push back. That cracked the door open. Then resistance training went main mainstream, bringing with it an interest in protein, creatine, and caffeine. The vaccine debate got heated, the evening news health segment lost credibility, and a realization set in: We are all responsible for our own health. Now the conversation has moved well past Reductratide could reshape obesity, peptides are circulating through compounding pharm

Doctor. Huberman, welcome to the A16Z Show.

Thank you. Delighted to be here.

I wanna talk about what's happened over the last five years. Like, since you launched your podcast, there's been an extreme increase in consumer interest and focus on their own health. Like, as an investor, we used to kind of think people were only willing to spend on what we'd like called sex or vanity drugs, like Propecia, Viagra, and that has totally changed in the last five years, and people are really interested in their health. I'm curious what you think the major drivers of that have been, and what your role has been in it.